Six strains chosen because they don’t produce histamine, 144 billion CFU in every scoop, and support for DAO, the enzyme that clears histamine from the gut.* A powder, so there is nothing in it but the bacteria.

Histamine is not only about allergies. It is tied to estrogen and progesterone, and when those two start to swing in perimenopause, histamine can swing with them. Here is the connection researchers are describing.

Research suggests estrogen can prompt mast cells to release histamine, and histamine in turn nudges the body to make more estrogen. In perimenopause, estrogen rises and falls unpredictably, so the loop gets noisier.

Progesterone is linked to steadier mast cells and better activity of DAO, the enzyme that breaks histamine down. It is also the hormone that declines first, often years before periods stop.

Most of the histamine you take in from food is broken down by DAO in the gut lining. The bacteria living there matter too: some common probiotic strains produce histamine of their own.
Many of these overlap with histamine. If several sound familiar, it is worth raising with your healthcare practitioner. Histamine Reducing Probiotic is a dietary supplement, not a treatment for menopause.
Some of the most common probiotic strains, the ones in many yogurts and capsules, produce histamine as they ferment. For a sensitive body that can mean feeling worse on a probiotic, not better. This blend leaves those out and uses six strains that fit a low-histamine approach, with a scoop of 144 billion CFU so a small dose goes a long way.
“During the first 2-3 weeks didn’t notice much change, however after the initial period started to notice real difference both in digestion as well as tolerance level. Already on the second bottle.”
“Working awesome. Starting to eat more foods! Even high histamine foods!”
“I have been using this product for two years and it is very very helpful for reducing a runny nose due to environmental irritants and or walking past perfume / household deodorizer aisle in store.”
“It seems that I have had less painful red cheek flare ups since using this product. Thanks!”
“This probiotic is surprisingly very good since it is a powder with NO other ingredients or fillers. I have to look high and low to find one like this.”
“I’ve been feeling great taking body ecology histamine reducer. Not much of a taste to it. Easy to drink with just water or adding it to a smoothie.”



30 g of pure probiotic powder, about 47 servings. One scoop in water, a smoothie or any liquid, 1 to 2 hours before a meal. Two stainless steel measuring scoops come in the box.
Proprietary probiotic blend, 600 mg per serving, 144 billion CFU. Serving size 0.6 g, about one large scoop. Approximately 47 servings per container.
Capsules need fillers and flow agents. A powder does not, which is why this one is just the six strains and nothing else.
Three ways people try to get on top of histamine, side by side.
| Histamine Reducing Probiotic | A regular probiotic | Low-histamine diet alone | |
|---|---|---|---|
| Leaves out histamine-producing strains | ✓ | Often includes them | Not applicable |
| Supports DAO, the histamine-clearing enzyme* | ✓ | ✕ | ✕ |
| Works on the gut, where histamine is cleared | ✓ | ✓ | ✕ |
| Lowers histamine coming in from food | ✕ | ✕ | ✓ |
| Free of dairy, sugar, gluten, soy and fillers | ✓ | Varies | Not applicable |
Most customers pair it with a lower-histamine way of eating. The two do different jobs.
Founded by Donna Gates, a pioneer of the gut-health movement.
Formulated for people who react to what is in most other probiotics.
Customers who come back year after year for the same reason: it works for them.
The questions we hear most about Histamine Reducing Probiotic.
Mix one large scoop (the “tad” scoop in the box) into water, a smoothie or any liquid, 1 to 2 hours before a meal. Many customers take it first thing in the morning or at bedtime. Keep the tub in the fridge to protect potency.
Reviewers often describe a quiet first two to three weeks, then a change in what they can eat and how they react. One tub is about 47 servings, so give it the full tub before you judge it.
Almost nothing. Customers describe it as nearly flavourless in water and easy to hide in a smoothie.
It was formulated for people who are sensitive to histamine, including those who have felt worse on ordinary probiotics. If you are pregnant, nursing, taking medication or have a medical condition, check with your practitioner first.
None listed. It contains no dairy, sugar, gluten, soy, casein, yeast, eggs, fish, shellfish, peanuts, tree nuts, corn, FOS, artificial colours, flavours or preservatives, and is non-GMO.
Yes. Customers commonly pair it with the GI Distress Relief Probiotic or Body Ecology kefir, and with the Body Ecology Diet.

Six strains, 144 billion CFU per scoop, nothing else in the tub.
Get Histamine Reducing Probiotic →