Regenerative therapy for anti-aging and skin renewal is the latest buzz among celebrities, and it's easy to understand why.
- Dr. Ellen Marmur, dermatologist
Increasing circulation to your skin will supply your cells with much-needed oxygen to improve sagging, wrinkles, and even age spots. Regenerative therapy is popular among celebrities hoping to enhance both health and the quality of their skin. A daily, living probiotic can also support a skin renewal treatment — the potassium and sulfur in CocoBiotic help to naturally increase circulation in the skin.
Have you ever peeked in the mirror after exercising? You may notice that your skin glows. After a tough workout, our skin becomes dewy with sweat, and usually the cheeks or the entire face is flushed pink. This is a good sign. It is evidence that the outermost reaches of our cells have been bathed in oxygen-rich blood. When you increase circulation to the most peripheral areas of the body, you can improve damage to skin cells, age spots, wrinkles, and sagging skin from weak collagen structure!
While our inner health deserves the most attention when it comes to improving the health and appearance of the skin, there are several proven natural treatments that can manage and potentially reverse skin damage that has already occurred.
Oxygen and your body
Oxygen, the third most abundant element in the universe, may prove to be one of the most effective treatments for the telltale signs of age that crop up unannounced. When cells do not receive enough oxygen, they slowly begin to malfunction and die. In a 2010 Japanese study, mice were exposed to UVB rays, known to prematurely age the skin. Those placed in an oxygen chamber after UVB exposure developed fewer wrinkles and showed fewer signs of tissue damage overall.2
Oxygen’s role as a life-giver in our universe is fascinating, and we can see the same effect, on a smaller scale, inside the human body. We are so dependent on oxygen that each blood cell is equipped with 280 million molecules of hemoglobin. When tissue in the body becomes damaged, it is unable to receive full support from surrounding blood vessels. This could happen in the brain, in the muscle tissue, in the joints, or in the organs.
So, what is Regenerative Therapy?
To find the answer, let’s dig into the science behind it. The human body is made up of 37.2 trillion cells.12 In Molecular Biology of the Cell, Lodish et al estimated that each of your individual cells can be damaged up to a million times daily!13
DNA damage occurs naturally every day for a variety of reasons, including: normal cellular metabolism,14 radiation from UV sunlight,14 cigarette smoke,14 environmental pollutants,14 chemicals,14 stress,15 and even errors during the DNA replication process.16
With all of that damage, you may be wondering how we even survive at all! Your body is pretty incredible and generates new cells every day. While it cannot prevent cell damage, regenerative therapy helps your body heal your cells after they have been damaged. Regenerative therapies deliver vital oxygen to your body to speed up recovery, ease arthritic pain, improve the quality of the skin, and even reduce inflammation in conditions like multiple sclerosis.
The cutting-edge comparison of NanoVi™, Hyperbaric chambers, and oxygen therapy.
The NanoVi™ device was designed to stimulate repair at the cellular level — producing a specific signal that is bioidentical to the body’s own natural signal which initiates its repair process. This is a therapy I personally use at home. The portable, table-top device emits a humidified air stream. Breathing in the enriched, humidified air can assist to body's own repair processes.
Hyperbaric Oxygen Therapy (HBOT) also aids your body’s natural ability to repair cell damage, but in a different way. HBOT takes place in a high-pressure, oxygen-rich chamber which delivers 100% oxygen to your body.
What Makes Regenerative Therapy So Effective?
While there is no magic bullet in health, there are certain essential mechanisms in the body that must work correctly in order to be healthy. One such mechanism is blood flow, or perfusion. Put simply, each and every cell in the body needs oxygen and nutrients that it can only receive from blood.
The act of breathing in air does not promise that each cell is receiving what it needs to thrive. In fact, for one reason or another, most of us are not getting the amount of perfusion that we need.
Not only does oxygen feed the cells, but healthy blood flow also carries away waste products like cellular debris and dangerous free radical toxins. Hyperbaric and other forms of oxygen therapy increase the oxygen outside of the cell respiration chain. Supplying additional oxygen to cells does not increase the cells’ ability to utilize more oxygen. To increase cells’ ability to utilize oxygen, the inner cell respiration chain has to be improved.
While regenerative therapy can be used to treat a wide array of serious health conditions, ranging from traumatic brain injury to gut function, they also just make you feel good:
- Several celebrities are known to own regenerative therapy systems -- Keanu Reeves, John Travolta, Kirstie Alley to name a few. Even Michael Jackson was reported to have his own personal “Fountain of Youth.”
- Many NFL athletes own their own NanoVi™ systems or HBOT chambers. These systems help them heal up quickly after an injury.
- Regenerative therapy has been used successfully by war veterans and trauma survivors to relieve post-traumatic stress disorder (PTSD).3
- Some stroke victims have used regenerative therapy to encourage full recovery; the treatment has been proven to boost brain repair years after stroke or traumatic brain injury.4
- Sick pets have benefited from regenerative therapy under a veterinarian’s care, with treatment for infection, rattlesnake bites, and injuries after being hit by a car.
Regenerative Therapy fights inflammation by bathing the cells in the body with oxygen.
In 2013, University of Edinburgh researchers confirmed that oxygen levels play a major role in determining the severity of the body’s inflammatory response.8 Researches discovered this while studying how oxygen in the body can affect the use of anti-inflammatory drugs.8 When you consider that chronic inflammation can disrupt a healthy blood system, potentially increasing cancer risk (as a University of California San Francisco research team discovered in 2016), the use of oxygen therapy to calm inflammation makes perfect sense.9
The NanoVi™ helps the body utilize more of the oxygen available. The HBOT delivers more oxygen to the body in a closed chamber. This oxygen easily enters into every tissue of the body, thus dramatically diminishes the appearance of wrinkles in the skin.
Regenerative technology directly encourages overall skin health:
- The surface of the skin and the tissue that structurally supports the skin rely on a constant supply of nutrients, especially oxygen.
- When cells do not receive enough oxygen, they slowly begin to malfunction and die.
This means that both the NanoVi and HBOT help the skin after trauma, injury, or surgery. A therapeutic dose of oxygen can also improve skin infections, and it can be especially useful in regulating the appearance of chronic acne. Even fungal skin infections and dandruff, also called scalp dermatitis, will noticeably benefit from increased circulation and healthy blood flow.
Regenerative therapy for Anti-Aging: How to Revive Tired Skin
Dermatologist Ellen Marmur, MD, associate professor of dermatology at Mount Sinai School of Medicine, says, “We tend to focus on the cardiovascular benefits of physical activity, and those are important. But anything that promotes healthy circulation also helps keep your skin healthy and vibrant.”
This is one of the reasons why facial acupuncture or even frequent facial massage can help smooth away wrinkles.2
We do everything in our power to hide these signs of age, but interestingly enough, research indicates that wrinkles could serve a deeper purpose, providing a better picture of our internal health. A study presented at The Endocrine Society's 93rd Annual Meeting in 2011 showed that the deeper a woman’s skin wrinkles in the first years of menopause are, the lower her bone density will be — a precursor to osteoporosis.1
NanoVi™ -- the Anti-Aging Therapy You Can Use at Home
The NanoVi™ is a relatively new pioneering technology with an array of benefits. I’ve had one for several years now and recently upgraded to a newer unit. I became convinced I had to spend the money once I read the research showing how effective the NanoVi™ is with respect to inflammation, which underlies every disease we have today, even aging.
when using their NanoVi™ devices.
But what really sold me was the effect it has on sleep, which is why I finally purchased one for myself and my family. It’s a stress-buster and is wonderfully relaxing when used any time of the day, but when used at bedtime, it switches off the brain signals that keep us awake. For me, it stops the mind-chattering that so many of us have once we crawl between those covers, especially as women. I recently purchased a new NanoVi™ because it has a setting that allows it to run through the night. Now I can help increase oxygen utilization and initiate repair while I sleep.
Deep, restful sleep is essential for rejuvenation and healing — and also for beautiful skin. Great for use in a spa or skincare salon, the NanoVi™ initiates skin strengthening at the cellular level, improving the body’s own ability to address oxidative damage and to repair damage from outside sources that is unavoidable. While the NanoVi™ can be complementary to HBOT, it's important to note that cells can't metabolize more oxygen without generating more free radicals. So, hyperbaric chambers should be used with caution and preferably under medical guidance.
When hyperbaric oxygen therapy is used for anti-aging or rejuvenation, it's best paired with the NanoVi™ device, a combination that has been shown to improve patient outcomes at HBOT centers. And though the NanoVi™ can safely initiate cellular repair at home, unregulated soft chambers for home use (including HBOT) are not recommended since the pressure may not be high enough to kill all harmful pathogens.
If you are a practitioner, you may want to offer NanoVi™ treatments in your office. In fact, a number of NanoVi™ devices have been purchased by functional medicine MDs, DOs, and naturopaths. NanoVi™ units can also be found in some gyms, workout studios, and physical therapists’ offices. When athletes used the NanoVi Pro™ device for 15 minutes before exhaustive exercise, University of Vienna researchers detected up to 17 percent lower blood lactate levels in the treatment group versus the placebo group.10
Hyperbaric Oxygen Therapy (HBOT)
Hyperbaric Oxygen Therapy takes place in a high-pressure, oxygen-rich chamber. The FDA has cleared HBOT for use in certain cases, though the safety and efficacy of the treatment have not been proven for all conditions. HBOT is a service that some insurance companies may cover if the diagnosis falls under FDA clearance. For more serious illnesses and medical conditions, it is always important to use HBOT under the care of your doctor. (Most states require a doctor’s prescription.)
The latest research on Hyperbaric Oxygen Therapy has been encouraging for sufferers of those “mysterious” maladies with symptoms that are hard to treat. In 2015, Rice University researchers found that women with fibromyalgia saw benefits after receiving the treatment — providing possible treatment options for other physical and mental conditions related to cognitive impairment, fatigue, irritable bowel syndrome, and sleep disturbance.5
High-dose HBOT has also been used to extend the survival window after cardiac arrest, even enhancing the effectiveness of the natural compound artemisinin used as an alternative cancer treatment.6,7
In a nutshell: Increased blood flow to the skin makes us more beautiful, and the science shows this much is true. Studies have long supported HBOT’s use in medicine, but a 2014 review published in Medical Gas Research found great potential for using oxygen therapy to refresh aging skin, though more research may be needed on treatment specifications and dose. “The use of high oxygen concentration to reduce the visibility of wrinkles have shown to be promising and effective to a certain degree since this treatment is currently being used and is becoming more widespread in spas and dermatology clinics worldwide,” the researchers wrote.11
By Donna Gates
Regenerative Therapy will not only improve the quality of your skin to treat wrinkles and sagging, but it may be used to alleviate serious health conditions, including injuries, PTSD, and stroke.
The NanoVi™ can help stimulate skin renewal, regulates sleep, and supports overall health by helping the body to better utilize oxygen. When used regularly, this convenient at-home device supports anti-aging in the body and in the skin. The NanoVi™ may also improve vitality and support better mental and physical performance — all by aiding in cellular repair.
Hyperbaric Oxygen Therapy provides advanced healing by bathing the body in oxygen to feed cells and stimulate blood flow. This increase in circulation will flush out cellular waste and cleanse harmful free radicals from the system. HBOT is most frequently used to promote healing after injury, trauma, or surgery. And while most research focuses on this treatment’s ability to improve and manage illness and poor health, the latest studies point to HBOT’s restorative effect on the skin. Using a high concentration of oxygen has been proven to be promising and effective to reduce the visibility of wrinkles.
- "Severity of facial wrinkles may predict bone density in early menopause, study suggests." The Endocrine Society.
- Yun Y, Kim S, Kim M, Kim K, Park J-S, Choi I. Effect of Facial Cosmetic Acupuncture on Facial Elasticity: An Open-Label, Single-Arm Pilot Study. Evidence-based Complementary and Alternative Medicine : 2013;2013:424313. doi:10.1155/2013/424313.
- Eovaldi B, Zanetti C. Hyperbaric oxygen ameliorates worsening signs and symptoms of post-traumatic stress disorder. Neuropsychiatric Disease and Treatment. 2010;6:785-789. doi:10.2147/NDT.S16071.
- Shai Efrati, Gregori Fishlev, Yair Bechor, Olga Volkov, Jacob Bergan, Kostantin Kliakhandler, Izhak Kamiager, Nachum Gal, Mony Friedman, Eshel Ben-Jacob, Haim Golan. Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients - Randomized, Prospective Trial. PLoS ONE, 2013; 8 (1): e53716 DOI: 10.1371/journal.pone.0053716.
- Shai Efrati, Haim Golan, Yair Bechor, Yifat Faran, Shir Daphna-Tekoah, Gal Sekler, Gregori Fishlev, Jacob N. Ablin, Jacob Bergan, Olga Volkov, Mony Friedman, Eshel Ben-Jacob, Dan Buskila. Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLOS ONE, 2015; 10 (5): e0127012 DOI: 10.1371/journal.pone.0127012.
- Van Meter K, Sheps S, Kriedt F, Moises J, Barratt D, Murphy-Lavoie H, Harch PG, Bazan N. Hyperbaric oxygen improves rate of return of spontaneous circulation after prolonged normothermic porcine cardiopulmonary arrest. 2008 Aug;78(2):200-14. doi: 10.1016/j.resuscitation.2008.02.026. Epub 2008 May 16.
- Yusuke Ohgami, Catherine A. Elstad, Eunhee Chung, Donald Y. Shirachi, Raymond M. Quock, Henry C. Lai. Effect of Hyperbaric Oxygen on the Anticancer Effect of Artemisinin on Molt-4 Human Leukemia Cells. Anticancer Research, 2010; 30: 4467-4470.
- A. Marwick, D. A. Dorward, C. D. Lucas, K. O. Jones, T. A. Sheldrake, S. Fox, C. Ward, J. Murray, M. Brittan, N. Hirani, R. Duffin, I. Dransfield, C. Haslett, A. G. Rossi. Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments. Journal of Leukocyte Biology, 2013; 94 (6): 1285 DOI: 10.1189/jlb.0912462.
- Eric M. Pietras, Cristina Mirantes-Barbeito, Sarah Fong, Dirk Loeffler, Larisa V. Kovtonyuk, SiYi Zhang, Ranjani Lakshminarasimhan, Chih Peng Chin, José-Marc Techner, Britta Will, Claus Nerlov, Ulrich Steidl, Markus G. Manz, Timm Schroeder, Emmanuelle Passegué. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nature Cell Biology, 2016; DOI: 10.1038/ncb3346.
- “Study of NanoVi™ Device – Impact on Immune Response.” University of Vienna, Center for Sports Science.
- Asadamongkol B, Zhang JH. The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging. Medical Gas Research. 2014;4:7. doi:10.1186/2045-9912-4-7.12.
- Bianconi E, Piovesan A, Facchin F, Beraudi A, Casadei R, Frabetti F, Vitale L, Pelleri MC, Tassani S, Piva F, Perez-Amodio S, Strippoli P, Canaider S. An estimation of the number of cells in the human body. Ann Hum Biol. 2013 Nov-Dec;40(6):463-71. doi: 10.3109/03014460.2013.807878. Epub 2013 Jul 5. Erratum in: Ann Hum Biol. 2013 Nov-Dec;40(6):471. PMID: 23829164
- Lodish, H., et al. Molecular Biology of the Cell, 5th ed. (New York, Freeman, 2004)
- DNA Damage and Skin Cancer: It’s Not all About the Sun, Harvard University Graduate School of Arts and Sciences blog, Nov. 15, 2012 http://sitn.hms.harvard.edu/category/flash/
- Hara MR1, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.
- Sprouse, E., What Causes DNA Mutation?, Science How Stuff Works https://science.howstuffworks.com/life/genetic/dna-mutation.htm, online.
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